Table 3.

Summary of the LDA results for DNA LN and SG models vs. RNA 2S folding representations

TI	Ac (%)	Se (%)	Sp (%)	Final TIs	Vars.	λ	F	p	Ref.
Primary structure of DNA nucleotide & LN
LNθk	78.33	72.59	79.84	LNθ0	1	0.74	230.5	0.0001	a
LNπk	81.73	78.52	82.58	LNπ0, LNπ1, LNπ5,	3	0.89	76.3	0.0001	a
LNξk	90.87	82.96	92.95	LNξ1, LNξ5	2	0.82	142.1	0.0001	a
Pool	92.88	75.56	97.46	LNθ0, LNπ0, LNξ1, LNξ5	4	0.83	130.8	0.0001	a
Primary structure of DNA nucleotide sequences & SG
SGθk	66.25	81.48	62.23	SGθ1e, SGθ4e	2	0.78	69.62	0.001	a
SGπk	71.21	85.19	67.51	SGπ0e, SGπ2e, SGπ5e	3	0.76	49.54	0.001	a
TIk	75.39	68.15	77.30	W, Je, 0Xe	3	0.73	58.19	0.001	a
Pool	81.58	68.15	85.13	SGπ5e, H, 1XRe	3	0.67	79.94	0.001	a
Primary structure of DNA codon sequences & SG
SGθk	70.43	76.30	68.88	SGθ0, SGθ1, SGθ4e	3	0.75	52.31	0.001	a
SGπk	74.77	82.96	72.60	SGπ4, SGπ4e, SGπ5e	3	0.74	56.37	0.001	a
TIk	76.16	59.26	80.63	S, 0X, 1XRe	3	0.72	60.98	0.001	a
Pool	80.80	74.81	82.39	SGθ0, SGθ4e, SGπ4e, SGπ5e, W	5	0.67	47.04	0.001	a
RNA electrostatic parameter of thermodynamically-driven 2S folding
2Sθk	97.60	93.30	100.00	2Sθ0	1	0.34	724.47	0.001	b
2Sπk	93.83	83.70	98.89	2Sπ0, 2Sπ2	2	0.44	515.03	0.05	c
2Sξk	96.58	85.19	100.00	2Sξ0, 2Sξ1	2	0.41	38.8	0.001	d

Note: the terms Ac, Se, and Sp mean accuracy, sensitivity and specificity, and measure the ratio of the number of total, Mps, or Cgs sequences correctly classified by the model with respect to the real classification; Vars.=no of variables in the QSAR equations; SG=star-graph; LN=lattice network; 2S=secondary structure; super index “e” represents the embedded calculations; references (Ref.) are a: this work, b: (González-Díaz et al., 2007c), c: (González-Díaz et al., 2005a) and d: (González-Díaz et al., 2006a).