Fig. 4.

Sequence alignment of polymerases of CSFV and HCV. The CSFV NS5B sequence has been truncated in the N-terminus and C-terminus. The HCV sequence has been truncated in the C-terminus. These sequences were aligned as described in Section 2. Asterisks below alignment indicate identical residues and dots indicate similar residues. Lowercase letters indicate secondary structure assignment according to the PHD predicted results and PDB data (h, helix and s, strand). The sequence in the fingers and palm domains containing the conserved motifs is underlined with different colors. Strictly conserved residues are marked with solid red triangles. Residues mostly conserved are marked with hollow red triangles.