Fig. 7.

The rGTP complex. The position of the rGTP sites were derived by superposition of the HCV polymerase structure. The CSFV NS5B/rGTP complex has been rotated 180° clockwise around a parallel axis in (A) and (B). (A) A ribbon diagram of the complex structure. The rGTP is in brown. (B) A stereoview of the rGTP-binding site of NS5B/rGTP complex aligned with the structure of NS5B. The residues involved in the rGTP-binding site and the rGTP are depicted as stick models. The rGTP and Mn²⁺ion are shown in brown and grey, respectively. Active site residues are labeled and shown in cyan. The hydrogen bonding pattern between them is shown by green dot line. (C) CSFV NS5B without any ligand. (D) CSFV NS5B/rGTP complex structure. The rGTP's van der Waals surfaces are in brown. These structures have been rotated 60° forwards around a parallel axis. The C-terminal has been removed for clarity. The protein is colored according to Fig. 6A.