Table 1.

Cox regression analyses for all investigated causes of death, utilizing explanatory variables as in the primary analysis, excluding current antipsychotic exposure.

Cardiovascular
	HR	CI (95%)		P
Antipsychotic medication
Cumulative exposure
0 DDDs	Reference
0 > DDDs ≥ 90	1.95	1.83	2.09	< 0.001
90 > DDDs ≥ 365	1.68	1.53	1.84	< 0.001
365 > DDDs ≥ 730	1.24	1.04	1.48	< 0.05
730 > DDDs	0.89	0.67	1.18	0.429
Explanatory variables
Demographic factors
Female	0.69	0.65	0.73	< 0.001
Age at diagnosis	0.80	0.79	0.81	< 0.001
Other medication
Cardiac risk factors	2.47	2.29	2.68	< 0.001
Proxy markers of severity
Psychiatric bed days = 0	Reference
Psychiatric bed days 1–9	1.01	0.91	1.13	0.836
Psychiatric bed days ≥ 10	1.06	0.70	1.60	0.783
Psychiatric outpatient contacts = 0	Reference
Psychiatric outpatient contacts: 1–5	1.35	1.27	1.43	< 0.001
Psychiatric outpatient contacts: 6–10	1.20	1.10	1.30	< 0.001
Psychiatric outpatient contacts > 10	0.88	0.80	0.97	< 0.01
Living in an institution	1.14	1.04	1.24	< 0.01
Co-morbidity
Psychiatric co-morbid score	1.32	1.27	1.37	< 0.001
Somatic co-morbid score	1.26	1.23	1.29	< 0.001

Cancer
	HR	CI (95%)		P
Antipsychotic medication
Cumulative exposure
0 DDDs	Reference
0 > DDDs ≥ 90	1.85	1.65	2.08	< 0.001
90 > DDDs ≥ 365	1.19	1.00	1.43	0.057
365 > DDDs ≥ 730	0.97	0.69	1.37	0.878
730 > DDDs	0.46	0.25	0.85	0.013
Explanatory variables
Demographic factors
Female	0.69	0.63	0.76	< 0.001
Age at diagnosis	0.79	0.78	0.81	< 0.001
Other medication
Cardiac risk factors	0.53	0.48	0.59	< 0.001
Proxy markers of severity
Psychiatric bed days = 0	Reference
Psychiatric bed days 1–9	0.92	0.75	1.12	0.401
Psychiatric bed days ≥ 10	0.68	0.28	1.64	0.393
Psychiatric outpatient contacts = 0	Reference
Psychiatric outpatient contacts: 1–5	1.42	1.28	1.58	< 0.001
Psychiatric outpatient contacts: 6–10	1.21	1.06	1.39	< 0.01
Psychiatric outpatient contacts > 10	0.63	0.52	0.76	< 0.001
Living in an institution	0.94	0.79	1.11	0.454
Co-morbidity
Psychiatric co-morbid score	1.34	1.26	1.42	< 0.001
Somatic co-morbid score	1.84	1.79	1.90	< 0.001

Infection
	HR	CI (95%)		P
Antipsychotic medication
Cumulative exposure
0 DDDs	Reference
0 > DDDs ≥ 90	2.37	2.09	2.68	< 0.001
90 > DDDs ≥ 365	2.05	1.73	2.44	< 0.001
365 > DDDs ≥ 730	1.77	1.31	2.38	< 0.001
730 > DDDs	1.02	0.62	1.67	0.946
Explanatory variables
Demographic factors
Female	0.54	0.49	0.60	< 0.001
Age at diagnosis	0.78	0.77	0.80	< 0.001
Other medication
Cardiac risk factors	0.80	0.70	0.91	0.001
Proxy markers of severity
Psychiatric bed days = 0	Reference
Psychiatric bed days 1–9	1.12	0.93	1.36	0.233
Psychiatric bed days ≥ 10	1.38	0.74	2.59	0.314
Psychiatric outpatient contacts = 0	Reference
Psychiatric outpatient contacts: 1–5	1.17	1.03	1.32	0.013
Psychiatric outpatient contacts: 6–10	1.07	0.92	1.25	0.382
Psychiatric outpatient contacts > 10	0.72	0.60	0.86	< 0.001
Living in an institution	1.17	1.00	1.38	0.053
Co-morbidity
Psychiatric co-morbid score	1.32	1.23	1.42	< 0.001
Somatic co-morbid score	1.54	1.48	1.60	< 0.001

Intentional self-harm
	HR	CI (95%)		P
Antipsychotic medication
Cumulative exposure
0 DDDs	Reference
0 > DDDs ≥ 90	0.76	0.24	2.41	0.640
90 > DDDs ≥ 365	0.24	0.03	2.02	0.189
365 > DDDs ≥ 730	0.00	0.00		1.000
730 > DDDs	0.87	0.09	8.57	0.902
Explanatory variables
Demographic factors
Female	0.49	0.23	1.04	0.063
Age at diagnosis	0.82	0.74	0.91	< 0.001
Other medication
Cardiac risk factors	1.92	0.71	5.18	0.199
Proxy markers of severity
Psychiatric bed days = 0	Reference
Psychiatric bed days 1–9	2.70	0.79	9.23	0.113
Psychiatric bed days ≥ 10	10.48	1.12	98.42	< 0.05
Psychiatric outpatient contacts = 0	Reference
Psychiatric outpatient contacts: 1–5	1.51	0.58	3.90	0.400
Psychiatric outpatient contacts: 6–10	1.70	0.54	5.35	0.368
Psychiatric outpatient contacts > 10	0.53	0.10	2.96	0.471
Living in an institution	1.09	0.25	4.82	0.909
Co-morbidity
Psychiatric co-morbid score	2.94	2.02	4.27	< 0.001
Somatic co-morbid score	0.91	0.66	1.25	0.552

HR: hazard ratio; CI: confidence interval; DDD: daily defined dosage.