Table 2.
Analytical performance of SiNW based FET biosensors.
| Device specification | Fabrication | Mechanism | Application | Detection Limit | Ref. |
|---|---|---|---|---|---|
| p-type SiNW; diameter: 20 nm | Bottom-up | Biotin-avidin binding | Streptavidin | 10 p.M. | Cui et al. (2001) |
| p-type SiNW; diameter: 20 nm | Bottom-up | Antibody-virus interaction | Influenza A virus | Single virus | Patolsky et al. (2004) |
| n-type SiNW, p-type SiNW; diameter: 20 nm | Bottom-up | Antibody-antigen interaction | PSA, CEA, Mucin-1 | PSA: 2 fM, CEA: 0.55 fM, Mucin-1: 0.49 fM | Zheng et al. (2005) |
| p-type SiNW; diameter: 30–60 nm | Bottom-up | Protein-protein interaction | Troponin I | 7 nM | Lin et al. (2010) |
| p-type SiNW; diameter: 20 nm | Bottom-up | PNA-DNA hybridization | DNA | 10 fM | Hahm and Lieber (2004) |
| p-type multi-SiNW; width: 50 nm, thickness: 30 nm, length: 20 µm | Top-down | Antibody-antigen interaction | Insulin | 10 fM | Regonda et al. (2013) |
| p-type single-SiNW | Top-down | Antibody-antigen interaction | Antigen | 5 fM | Puppo et al. (2014) |
| n-type SiNW, p-type SiNW; thickness: 40 nm, width: 50–150 nm | Top-down | Biotin-avidin binding | Streptavidin | 10 fM | Stern et al., 2007a, Stern et al., 2007b |
| n-type poly-SiNW; width: 80 nm, lenght: 2 µm | Top-down | 4-carboxyphenylboronic acid-dopamine interaction | Dopamine | 1 fM | Lin et al. (2008) |
| n-type SiNW, p-type SiNW; thickness: 40 nm, width: 50–150 nm | Top-down | Antibody-antigen interaction | PSA, CA-15.3 | PSA: 2.5 ng mL−1, CA 15.3: 30 U/mL | Stern et al. (2010) |
| n-type SiNW; thickness: ≤40 nm | Top-down | Antibody-antigen interaction | PSA | 30 aM | Kim et al. (2007) |
| n-type SiNW; width: 50 nm, thickness: 60 nm, length: 100 nm | Top-down | Antibody-antigen interaction | cTnT, Creatine kinase-MM and MB | 1 pg/mL | Zhang et al. (2011b) |
| n-type SiNW; width: 50 nm, thickness: 60 nm, length: 100 nm | Top-down | Antibody-antigen interaction | cTnT | 1 fg mL−1 | Chua et al. (2009) |
| n-type Polycrystalline (poly) Si NW | Top-down | Antibody-antigen interaction | PSA | 5 fg/mL | Huang et al. (2013) |
| P-type SiNW; width: 60 nm, length: 10 µm | Top-down | Antibody-antigen interaction | Thyroid-Stimulating Hormone | 0.11 pM | Lu et al. (2014) |
| n-type SiNW; width: 50 nm, thickness: 60 nm, length: 100 nm | Top-down | Protein-DNA interaction | Endoplasmic reticulum | 10 fM | Zhang et al. (2011a) |
| n-type SiNW; width: 50 nm, thickness: 60 nm, length: 100 nm | Top-down | PNA-DNA hybridization | RT-PCR product of dengue serotype 2 | 10 fM | Zhang et al. (2010) |
| n-type SiNW; width: 50 nm, thickness: 60 nm, length: 100 nm | Top-down | PNA-DNA hybridization | microRNA | 1 fM | Zhang et al. (2009) |
| n-type SiNW; width: 50 nm, thickness: 60 nm, length: 100 nm | Top-down | PNA-DNA hybridization | DNA | 10 fM | Zhang et al., 2008a, Zhang et al., 2008b |
| n-type SiNW, p-type SiNW; width: 20 nm, length: 30 nm | Top-down | DNA-DNA hybridization | DNA | 10 pM | Bunimovich et al. (2006) |
| n-type SiNW, p-type SiNW; width: 50 nm, length: 20 nm | Top-down | DNA-DNA hybridization | DNA | 25 pM | Li et al., 2004, Li et al., 2005 |
| p-type SiNW; width: 20 nm, heights: 30 nm | Top-down | DNA-DNA hybridization | DNA | 10 fM | Nuzaihan et al. (2016) |
| p-type SiNW; width: 60 nm, heights: 200 nm | Top-down | DNA-DNA hybridization | DNA | 1 nM | Pengfei et al. (2013) |
| p-type SiNW; width: 20 nm, heights: 1000 nm | Top-down | DNA-DNA hybridization | DNA | 0.1 nM | Adam and Hashim (2014) |
| p-type SiNW; width: 50 nm, heights: 80 nm | Top-down | DNA-DNA hybridization | DNA | 1 pM | Ryu et al. (2010) |
| p-type SiNW; width: 40 nm | Top-down | DNA-DNA hybridization | DNA | 200 pM | Pham et al. (2011) |
| p-type SiNW; width: 20 nm | Top-down | DNA-DNA hybridization | DNA | 1 fM | Gao et al. (2011) |
| p-type SiNW; length: 16 µm | Top-down | DNA-DNA hybridization | DNA | 0.1 fM | Gao et al. (2012) |