Table 4.
Cytotoxic and cytostatic activity of the ligands and their platinum(II) and palladium(II) complexes.
| Compound | MICa (μM) |
IC50b (μM) |
|||||
|---|---|---|---|---|---|---|---|
| HEL | HeLa | MDCK | HEL | CrFK | HeLa | CEM | |
| 1a | ≥20 | 100 | 10.8 | 6.0 | 6.7 | 37 | 55 |
| 1b | 100 | >100 | >100 | 13.3 | 91.9 | 22 | 34 |
| 2 | ≥100 | 100 | 57.8 | 10.4 | 10.1 | 7.1 | 10 |
| 2a | 60 | 100 | 12.6 | 26.2 | 15.6 | 37 | 36 |
| 2b | 100 | >100 | >100 | 42.8 | >100 | 180 | 60 |
| 3 | ≥100 | ≥20 | >100 | 32.1 | >100 | 43 | 163 |
| 3a | 100 | 100 | 60.7 | 52.7 | 65.0 | 105 | 53 |
| 3b | ≥100 | 100 | 100 | 100 | >100 | 254 | 168 |
| 4 | ≥20 | ≥20 | 10.9 | 52.1 | 3.8 | 3.6 | 6.4 |
| 4a | 20 | 20 | 3.4 | 3.1 | 7.5 | 1.7 | 8.1 |
| 4b | ≥100 | 100 | 55.3 | 14.6 | 39.1 | 21 | 30 |
| 5 | ≥20 | 20 | >100 | 3.2 | 2.4 | 12 | 27 |
| 5a | ≥100 | >100 | >100 | 34 | >100 | 46 | 26 |
| 5b | >100 | >100 | >100 | 51.7 | >100 | 385 | 152 |
a
Minimal inhibitory concentration or compound concentration required to alter microscopically visible morphology of the confluent cell cultures.
b
50% Inhibitory concentration or compound concentration requred to inhibit MDCK (Madin Darby canine kidney), HEL (human lung fibroblast), CrFK (Cranell feline kidney), HeLa (human cervic carcinoma) or CEM (human lymphocyte) cells by 50%.