Fig. 5.

Proteolytic processing of EAV replicase polyprotein pp1a through the major and minor pathways. The papain-like cysteine protease (PCPβ) and cysteine protease (CP) cleavage sites are indicated by black arrows. The M^pro cleavage sites are indicated by open arrowheads. P and P* are, PCP and CP, respectively; M^pro, 3C-like main protease; C/H, cysteine/histidine-rich clusters; TM, predicted transmembrane domains.

Figure modified from Nidoviruses book chapter (Van Hemert and Snijder, 2008) with permission from the ASM Press.