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Formulation parameters included in the experimental design.
| Low level | Centre level | High level | |
|---|---|---|---|
| Concentration (mg/mL)a | 10 | 20 | 30 |
| Ratio (w/w)b | 0.2 | 0.5 | 0.8 |
| Excipient | Mannitol | Lactose | Trehalose |
Total amount of carbohydrate excipient and NP in the feed solution.
Relative amount of NPs (by weight) compared to the total amount of dry substance.
