Table 3.
Responses for optimization samples.
| Run no. | Formulation parameters |
Responses |
|||||
|---|---|---|---|---|---|---|---|
| Excipient | Ratioa | Concentration (mg/mL) | Yield (%) | Moisture content (%) (n = 1) | MMAD (µm) (n = 3) | Morphology | |
| 1 | Trehalose | 0.2 | 10 | 47.8 | 5.6 | 2.93 ± 0.05 | Smooth |
| 2 | Trehalose | 0.5 | 20 | 39.2 | 4.7 | 2.81 ± 0.24 | Raisin |
| 3 | Lactose | 0.8 | 30 | 45.5 | 2.1 | 3.07 ± 0.03 | Raisin |
| 4 | Lactose | 0.8 | 10 | 19.5 | 1.5 | 2.25 ± 0.08 | Raisin |
| 5 | Mannitol | 0.5 | 20 | 48.9 | 0.5 | 3.25 ± 0.06 | Raisin |
| 6 | Trehalose | 0.8 | 10 | 19.3 | 2.2 | 2.76 ± 0.15 | Raisin |
| 7 | Mannitol | 0.2 | 10 | 34.6 | 0.5 | 3.41 ± 0.02 | Smooth |
| 8 | Trehalose | 0.5 | 20 | 39.4 | 4.0 | 4.21 ± 0.05 | Raisin |
| 9 | Mannitol | 0.5 | 20 | 43.9 | 0.4 | 3.07 ± 0.10 | Raisin |
| 10 | Lactose | 0.5 | 20 | 33.0 | 3.7 | 2.73 ± 0.27 | Raisin |
| 11 | Lactose | 0.2 | 10 | 41.8 | 7.0 | 2.92 ± 0.05 | Smooth |
| 12 | Lactose | 0.5 | 20 | 36.7 | 5.0 | 3.55 ± 0.13 | Raisin |
| 13 | Mannitol | 0.8 | 10 | 31.2 | 0.5 | 2.54 ± 0.45 | Raisin |
| 14 | Trehalose | 0.8 | 30 | 46.1 | 2.2 | 3.90 ± 0.06 | Raisin |
| 15 | Mannitol | 0.2 | 30 | 56.4 | 0.5 | 4.84 ± 0.12 | Smooth |
| 16 | Mannitol | 0.8 | 30 | 42.4 | 0.4 | 3.28 ± 0.10 | Raisin |
| 17 | Lactose | 0.2 | 30 | 44.9 | 4.8 | 5.36 ± 0.56 | Smooth |
| 18 | Trehalose | 0.2 | 30 | 51.3 | 5.1 | 5.62 ± 0.10 | Smooth |
a
Relative amount of NPs ( by weight) compared to the total amount of dry substance.