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. 2001 Jun 26;88(3):183–204. doi: 10.1016/S0168-1656(01)00281-4

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Copyright © 2001 Elsevier Science B.V. All rights reserved.

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Fig. 4 — Single genome expression based on the engineering of coronavirus minigenomes by targeted recombination: A. Basic scheme of targeted recombination in MHV. The black box indicates the approximate location of the N gene region (87 nt) that is deleted in the Alb4 mutant. M, insertion of 5 nt used as a genetic marker (Masters, 1999). B. Targeted recombination within the S gene of TGEV and a minigenome carrying the information for an S gene with three nucleotide mutations (Sdmar) that allow escape from neutralization by two mAbs specific for antigenic sub-sites Ac and Aa of S protein (Sola et al., 2001b).