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. 2018 Jul 6;134:22–35. doi: 10.1016/j.addr.2018.07.003

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© 2018 Published by Elsevier B.V.

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Fig. 4 — Conformational change recognizing aptamers. (A) Allosterically modulating aptamers. RNA aptamers that specifically recognize the active state of β2-adrenoceptor (β2AR) act as allosteric modulators of the G-protein-coupled receptors (GPCR), binding at distinct sites to inhibit its signaling activity. (B) Homodimer-recognizing aptamers. DNA aptamers that are >100-fold specific for binding cJun/cJun as compared to cJun/cFos block binding of the transcription factor activator protein 1 (AP-1) DNA element and inhibit cJun homodimer transcription in cells.