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Anti-HIV-1 activity (IC50) and cytotoxicity (CC50) of chloroquine gels in MT-4 cellsa
| Chloroquine loading (mg/g) | CC50 |
IC50 |
|
|---|---|---|---|
| Gel (mg/ml) | Gel (mg/ml) | Chloroquine (μg/ml)b | |
| Placebo | > 100 | > 100 | – |
| 0.3 | > 100 | 44.7 | 13.4 |
| 1 | > 100 | 8.3 | 8.3 |
| 3 | > 100 | 1.9 | 5.6 |
| 10 | 44.7 | 0.8 | 7.9 |
| 30 | 9.6 | 0.3 | 8.1 |
Values represent one representative batch of gels.
The IC50-values for chloroquine were calculated based on the IC50-values for the gels and the chloroquine loading.
