Table 1.
Antiviral activity of camphor-based compounds 1–5 against influenza virus A/California/7/09 (H1N1)pdm09 in MDCK cells
| Compound | CTD50a, μM | ED50b, μM | SIc |
|---|---|---|---|
| 1 | 3289.5 ± 216.0 | 1644.7 ± 144.4 | 2 |
| 2a | 283.6 ± 25.4 | 9.3 ± 0.8 | 30 |
| 2b | 1346.6 ± 126.1 | 15.1 ± 1.1 | 89 |
| 2c | 1256.3 ± 114.2 | 22.8 ± 2.3 | 55 |
| 2d | 390.1 ± 35.9 | 24.2 ± 2.1 | 16 |
| 2e | 2216.2 ± 214.8 | 45.0 ± 3.9 | 49 |
| 2f | >1072.9 | 351.4 ± 32.3 | 3 |
| 2g | >1067.0 | 373.4 ± 35.1 | 3 |
| 3b | 5.4 ± 0.4 | 0.77 ± 0.1 | 7 |
| 3c | 10.4 ± 1.0 | 3.2 ± 0.2 | 3 |
| 3e | 14.4 ± 1.5 | 4.4 ± 0.3 | 3 |
| 3f | >638.2 | 153.2 ± 11.9 | 4 |
| 3g | >635.5 | 207.6 ± 19.5 | 3 |
| 4b | 110.3 ± 9.1 | 110.1 ± 10.4 | 1 |
| 4c | 697.6 ± 72.2 | 40.4 ± 3.8 | 17 |
| 5f | 30.1 ± 2.9 | 15.0 ± 1.2 | 2 |
| 5g | 32.9 ± 2.7 | 4.2 ± 0.0 | 8 |
| Rimantadine | 335.2 ± 26.8 | 67.0 ± 4.9 | 5 |
| Amantadine | 284.1 ± 21.4 | 64.2 ± 4.7 | 4 |
| Deitiforin | 1266.2 ± 81.5 | 208.6 ± 15.4 | 6 |
| Ribavirind | >2000.0 | 24.6 | >81.0 |
a
CTD50—cytotoxic concentration; the concentration resulting in death of 50% of cells.
b
ED50—50% effective concentration; the concentration leading to 50% inhibition of virus replication.
c
SI—selectivity index, ratio CTD50/ED50.
d
Data are taken from Ref. 29.