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. 2005 Nov 30;95(5):1084–1096. doi: 10.1016/S0091-6749(95)70212-1

FIG. 5.

FIG. 5

FIG. 5

Administration-time (7:00 AM versus 7:00PM) differences in terfenadine-and clemastine-induced inhibition of local cutaneous reaction to intradermally injected histamine (2 æg/0.1 ml). Double-blind protocol was used to test medication effects. Strength of antihistamine effect according to treatment time and dose is expressed as clock-time difference in cutaneous response to histamine during antihistamine versus placebo treatments. Antihistamine effect was longer in a dose-dependent manner when medications were ingested in the morning. Magnitude of peak effect was greater in a dose-dependent manner after evening treatment. (From Reinberg A, et al. Eur J Clin Pharmacol 1976;14:245-52, by permission of Elsevier Science Publishers.)