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. 2005 Nov 30;95(5):1084–1096. doi: 10.1016/S0091-6749(95)70212-1

TABLE I.

Mean (±standard error) use of handkerchiefs by cold and influenza sufferers by clock time*




Clock times
Type of virus No. of subjects Study days 8-11 am 11 am-2 pm 2-5 pm 5-8 pm 8-11 pm
Cold 19 1 and 2 4.6 ± 0.7 3.6 ± 0.9 3.7 ± 1.0 3.6 ± 0.9 4.0 ± 0.6

Cold 19 3 and 4 4.8 ± 1.1 2.8 ± 0.8 2.8 ± 1.0 1.8 ± 1.0 1.8 ± 0.6

Influenza 3 All 7.1 ± 2.8 1.9 ± 0.6 2.2 ± 1.2 1.9 ± 1.2 3.7 ± 2.4

Data from Smith A, et al. Chronobiol Intern 1988;5:441.

*By analysis of variance, time-of-day differences in handkerchief use were statistically significant (p < 0.05) for symptomatic days 1 and 2 and 3 and 4 by cold and by influenza sufferers