Table 1.
A comparison of disorder levels (PID) of the nucleocapsid (N) proteins across NiV types with CFR.
| Outbreak Strains | Number of Cases (Deaths) | Fatality Rate (CFR, %)a | PID (%) N | UniProt accession numbers |
|---|---|---|---|---|
| Malaysia-Singapore 1998-99 | 276 (106) | 38 | 41.73 ± 0.01b | Q9IK92, A0A1LK92 |
| Bangladesh-India 2001–2005 | 170 (123) | 72 | 42.67 ± 0.27b | Q4VCQ2, H6V858 |
| Bangladesh-India 2007-10 | 103 (88) | 85 | 43.32 ± 0.24b | D2DEB7, A0A141HUS6c, H6V855, H6V857, E4Z9F9d |
Statistical Analyses: ANOVA, p < 0.01, Regression Analysis, p < 0.01, r2 = 0.93.
a CFR are calculated from the total number of death divided by the total number of cases.
b The numeric value after “+” is the standard error. It should be noted that the mean PID values are misleadingly close to each other. It does not need to be the case since the N protein is huge and most of the mutations arise from or from areas close to the Ntail.
b Samples from two anamalous strains are not included: H6V868, H6V854. In general, a few anamalous strains should be expected in cases where a large number of outbreaks/strains is involved. The data used involve 9 isolates and 6 strains.
c This Thailand sample was collected in 2010 from bats. This sample makes the study interesting as the PID and genetic makeup is closer to those of the Bangladesh-India 2007-10 group despite the fact that Thailand is geographically closer to Malaysia-Singapore. However, because the PID and genetic makeup is closer to that of the 2008-10 strains and because 2007 is close to 2008, we suspect that this strain falls into the 2008-10 strains.
d Sample was collect from Malaysian bats in 2008. It is of great interest since its PID and genetic makeup is closer to the Bangladesh-India 2007-10 samples than to those of Malaysia-Singapore 1998–99.