Table 1.

In vitro EC₅₀ data for HSV-1 and HSV-2 assays

	Toxicity	Antiviral activity (EC50)		Selectivity index
	CC50	HSV-1	HSV-2	HSV-1	HSV-2
7c	0.15	0.08	0.07	0.07	2.03
7d	0.06	>0.06	0.03	<1.0	1.81
8c	0.26	0.09	0.09	2.88	2.83
ACV>	>10.00	0.18	0.36	55.76	>27.78
Ara-C>	>10.00	0.20	0.52	49.13	>19.38

EC₅₀ (μg/mL): Concentration of test compound required to inhibit virus-induced cytopaticity by 50%; CC₅₀ (μg/mL): concentration of test compound that causes 50% cytotoxicity to uninfected cells; selectivity index: CC₅₀/EC₅₀.