Table 2.
In vitro EC data for EMCV, Cox. B3, and VSV assays
| Toxicity | Antiviral activity (EC50) |
Selectivity index |
|||||
|---|---|---|---|---|---|---|---|
| CC50 | EMCV | Cox. B3 | VSV | BMCV | Cox. B3 | VSV | |
| 7c | 0.05 | 0.01 | 0.01 | 0.03 | 4.91 | 5.38 | 1.65 |
| 7d | 0.04 | 0.01 | 0.01 | 0.03 | 5.94 | 5.30 | 1.50 |
| 8c | 0.07 | 0.02 | 0.03 | >0.07 | 3.30 | 2.76 | <1 |
| Rib. | 0.30 | 0.02 | 0.04 | 0.08 | >13.91 | >7.69 | >35.22 |
EC50 (μg/mL): Concentration of test compound required to inhibit virus-induced cytopaticity by 50%; CC50 (μg/mL): concentration of test compound that causes 50% cytotoxicity to uninfected cells; selectivity index: CC50/EC50.