Table 6.
Cytotoxicity and antiviral activity in Vero cell cultures
| Compound | R | MCCa (μM) | EC50b (μM) |
|
|---|---|---|---|---|
| Coxsackie virus B4 | Punta Toro virus | |||
| trans-10a/cis-10a (93:7) | ||||
| (exp. 1) | H | >100 | 45 | >100 |
| (exp. 2) | >100 | 73 | >100 | |
| trans-10d/cis-10d(93:7) | ||||
| (exp. 1) | NHC(O)CH3 | >100 | 45 | 50 |
| (exp. 2) | >100 | 58 | 100 | |
| DS-10.000 (μg/ml) | ||||
| (exp. 1) | >100 | >100 | 45 | |
| (exp. 2) | >100 | >100 | 100 | |
| Ribavirin | ||||
| (exp. 1) | >250 | >250 | 112 | |
| (exp. 2) | >250 | >250 | 250 | |
a
Minimum cytotoxic concentration that causes a microscopically detectable alternation of cell morphology.
b
Effective concentration that is required to reduce virus-induced cytopathogenicity by 50%.