1. |
HDH I |
65 |
ATP, dATP |
First human DNA helicase reported in purified form and also functions as RNA helicase. |
2. |
HDH II/Ku |
72, 87 |
ATP, dATP |
DNA end binding protein and involved in dsDNA break repair. |
3. |
HDH III |
46 |
ATP, dATP |
Stimulated by fork-like structure of substrates. |
4. |
HDH IV |
100 |
ATP, dATP |
Can also function as RNA helicase. |
5. |
HDH V |
92 |
ATP, dATP |
Has highest turn over rate. |
6. |
HDH VI |
128 |
ATP, dATP |
Stimulated by fork-like structure of substrates |
7. |
HDH VII |
36 |
nd |
Trimer of one molecule of hnRNP A1 and two molecules of annexin II |
8. |
HDH VIII |
68 |
ATP |
Functions both as DNA and RNA helicase. |
9. |
HDH IX |
45 |
nd |
It is a Gly Arg rich protein. |
10. |
XPD/ERCC2 |
87 |
ATP, dATP |
Functions in nucleotide excision repair; component of BTF2-TFIIH transcription factor. |
11. |
XPB/ERCC3 |
89 |
ATP |
Functions in nucleotide excision repair; component of BTF2-TFIIH transcription factor. |
12. |
Helicase ε
|
72 |
ATP, dATP, CTP |
Helicase activity is dependent on HRP-A. |
13. |
Helicase ∝
|
110 |
ATP, dATP, |
Stimulated by 5′-tailed fork and SSB. |
|
|
90 |
CTP, dCTP |
|
14. |
RIP 100 |
100 |
ATP, dATP |
Associated with RIP60 protein. |
15. |
Helicase Q1 |
73 |
ATP, dATP |
Gene homologous to E. coli RecQ gene. |
16. |
Helicase Q2 |
100 |
ATP |
Identical to DNA helicase IV. |
17. |
HchlR1 |
112 |
ATP |
Can unwind RNA/DNA substrates. |
18. |
HhcsA |
116 |
ATP, dATP |
Hexameric protein. |
19. |
WRN helicase |
163 |
ATP, dATP> |
Mutated in Werner syndrome, homologous to RecQ and contains 3′–5′ exonuclease activity. |
|
|
dCTP, CTP |
20. |
BLM helicase |
∼160 |
ATP |
Mutated in cells of Blooms syndrome patient and belongs to RecQ family. |
21. |
Mcm4/6/7 complex |
∼600 |
ATP, dATP |
Stimulated by SSB and forked DNA structures; can function as a replication helicase. |
22. |
HEL308 |
124.5 |
ATP, dATP |
Stimulated by RPA. |
23. |
hFBH1 |
∼120 |
ATP |
First F-box protein with helicase activity. |
24 |
Human RECQ1 |
75 |
ATP |
Stimulated by hRPA and can also unwind blunt end substrate with bubble of 25 nt. |
25 |
BACH1 |
130 |
ATP |
Involved in dsDNA break repair. |