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. 2009 Feb 9;19(6):1636–1638. doi: 10.1016/j.bmcl.2009.02.010

Table 1.

IC50 values of ADKs against SCV Hel ATPase activity and duplex DNA-unwinding activity

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Compound IC50 (μM)
ATPase Duplex DNA-unwinding
1 41.3 ± 2.7 39.9 ± 0.5
2 >50 >50
3 >50 >50
4 24.4 ± 1.0 13.6 ± 0.3
5 >50 >50
6 >50 28.7 ± 2.3
7 >50 5.4 ± 0.1
8 >50 11.0 ± 0.6