Figure 3.

Possible Improvements in Monoclonal Antibody(mAb)-Based Antiviral Immunotherapies. The identification of the molecular and cellular mechanisms responsible for the induction of vaccine-like effects by antiviral mAbs will be paramount to the improvement of future antiviral passive immunotherapies. They are currently the object of intense research. Furthermore, several possibilities pertaining to the conditions of mAb administration, the mAbs themselves, and their targets, can already be considered. These include combined therapies affecting viral propagation and/or enhancing immune responses; engineering mAbs to improve their effector functions, i.e., increasing their binding to Fcγ receptors (FcγRs) by affecting their glycosylation or their amino acid sequence; pertinent selection of their isotype; taking into account FcγR polymorphisms in patients to be treated; and selecting the most appropriate viral antigens.