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(A) Effect of twice-daily oral treatment with 200 mg/kg of T-705 beginning on day 1, 2 or 3 post-infection on the survival of WNV-infected C57Bl/6 mice. *P ≤ 0.05, **P ≤ 0.01 compared to placebo controls. (B) Immunohistochemical detection of WNV envelope glycoprotein on day 7 of infection in the brains of Syrian golden hamsters treated twice daily with 200 mg/kg of T-705 or with a placebo beginning on the day of infection. Scale bar: 50 μm (Morrey et al., 2008).
