Table 1.
In vitro antiviral activity of ethanol extract and compound 1−5 isolated from E. cava against PEDV
| Extract or compounds | CC50a (μM) | Simultaneous-treatment |
Post-treatment |
||
|---|---|---|---|---|---|
| IC50b (μM) | SIc | IC50b (μM) | SIc | ||
| EtOH extract | 533.6 ± 2.6 μg/mL | 12.4 ± 2.2 μg/mL | 43.0 | 19.5 ± 3.8 μg/mL | 28.3 |
| Phloroglucinol (1) | 374.4 ± 4.0 | — | — | — | — |
| Eckol (2) | 388.3 ± 2.6 | 22.5 ± 2.2 | 17.2 | — | — |
| 7-Phloroeckol (3) | 446.2 ± 3.8 | 18.6 ± 2.3 | 23.9 | — | — |
| Phlorofucofuroeckol (4) | 579.0 ± 4.3 | 10.8 ± 1.4 | 53.6 | 12.2 ± 2.8 | 47.4 |
| Dieckol (5) | 490.6 ± 1.6 | 16.6 ± 3.0 | 29.5 | 14.6 ± 1.3 | 33.6 |
a
CC50: mean (50%) value of cytotoxic concentration.
b
IC50: mean (50%) value of inhibitory concentration.
c
SI: selective index, CC50/IC50.