Table 1.

Effects of having a respiratory infection (RI) and of days with infection on body temperature and symptoms of sickness. The left part concerns the effects of condition and weekdays, and the right part the effects of condition and days with infection/being healthy.

Fixed effects	Mixed effects ANOVA (Effect of condition and weekday)						Fixed effects	Mixed effects ANOVA (Effect of condition and days with infection/being healthy)
	Body temperature			Symptoms				Body temperature			Symptoms
	F	p-value		F	p-value			F	p-value		F	p-value
Condition	1.4	0.248		102.04	<0.001	***	Condition	1.29	0.267		106.11	<0.001	***
Weekday	3.6	0.002	**	0.47	0.829		Days	1.85	0.093		21.16	<0.001	***
Time of day	9.75	0.004	**	0.22	0.643		Time of day	8.41	0.007	**	0.17	0.680
Condition: Weekday	0.62	0.713		1.35	0.232		Condition: Days	1.35	0.234		45.97	<0.001	***
Condition: Time of day	0.46	0.500		1.04	0.308		Days: Time of day	0.51	0.804		0.38	0.890
Weekday: Time of day	2.25	0.038	*	0.76	0.601		Condition: Time of day	0.97	0.326		2.78	0.096
Condition: Weekday: Time of day	0.87	0.518		0.86	0.526		Condition: Days: Time of day	1.59	0.149		1.61	0.143
Random effects	SD	N		SD	N		Random effects	SD	N		SD	N
Condition: Subjects	0.165	54		1.776	54		Condition: Subjects	0.168	54		1.798	54
Weekday: Subjects	0.063	196		0.802	196		Days: Subjects	0.059	196		0.841	196
Time of day: Subjects	0.127	56		0.151	56		Time of day: Subjects	0.128	56		0.499	56
Subjects	0.242	28		0.540	28		Subjects	0.241	28		0.523	28
Residual	0.305	703		2.437	708		Residual	0.307	703		1.753	708

The ANOVAs include the fixed effects of condition (period with RI vs healthy period), time of day (morning and evening), and weekday effects (in the left panel) and days with sickness or being healthy (in the right panel). The weekday effect is added as a factor to account for that subjects got sick at different days of the week. P-values have been calculated using Kenward-Roger adjusted denominator degrees of freedoms.