Table 1.

Diverse temperature profiles, IFN-γ secretion by PBMC and antibody titres from piglets after take of intranasal PRV NIA-3 infection (group A) and failure of productive infection (groups B and C)

Days after intranasal PRV application	IFN-γ secretion (pg/ml)	PRV-specific antibody titre 1	Body temperature (°C)	Animal no.: temperature response
Group A
6	2450	Not detectable	>40.5	21 fever
12	23450	1280	<40.0
19	30200	2800	<40.0
6	1838	Not detectable	>40.5	22 fever
12	17500	640	<40.0
19	30000	2078	<40.0
Group B
6 i.m. injection	<40	Not detectable	<40.0	25 moderate temp. rise
12	28400	160	>40.0
19	28400	2560	<40.0
6 i.m. injection	<40	Not detectable	40.0	29 short-term fever
12	18900	320	>40.0
19	32000	5120	<40.0
Group C
6 i.m. injection	<40	Not detectable	<40.0	24 no temperature rise
12	13892	5	>40.0
19	7500	6400	<40.0
6 i.m. injection	<40	Not detectable	<40.0	26 no temperature rise
12	9167	Not detectable	>40.0
19	73600	1600	<40.0
6 i.m. injection	<40	Not detectable	<40.0	27 no temperature rise
12	14800	Not detectable	>40.0
19	18000	1600	<40.0
6 i.m. injection	<40	Not detectable	<40.0	28 no temperature rise
12	12200	Not detectable	>40.0
19	35600	1600	<40.0

Response after second i.m. PRV application (day 6 post intranasal application) is indicated below the dotted lines and reflects a productive infection in animals from groups B and C accompanied by the development of fever (see Fig. 1). IFN-γ production and rise of body temperature in bold for day 6 post PRV application. i.m. = intramuscular.