Table 2.
Six key clinical trials of blood transfusion in adults.
| Clinical setting (Ref) |
Hemoglobin threshold (g/dl) | Age (years) | Patients transfused | Deviation from transfusion protocol | Mean hemoglobin at transfusion (g/dl) | Participation of eligible patients |
|---|---|---|---|---|---|---|
| Intensive care [64] | 7 vs 10 | 57.1 ± 18.1 58.1 ± 18.3 |
67% 99% |
1.4% 4.3% |
8.5 ± 0.7a 10.7 ± 0.7a |
41% |
| CT surgery [66] | 8 vs 10 | 58.6 ± 12.5 vs 60.7 ± 12.5 | 47% 78% |
1.6% 0.0% |
9.1 (9.0–9.2) 10.5 (10.4–10.6) |
75% |
| Hip fracture repair [67] | 8 vs 10 | 81.5 ± 9.0 vs 81.8 ± 8.8 | 41% 97% |
9.0% 5.6% |
7.9 ± 0.6 9.2 ± 0.5 |
56% |
| Acute upper GI bleeding [68] | 7 vs 9 | NA |
49% 86% |
9.0% 3.0% |
7.3 ± 1.4 8.0 ± 1.5 |
93% |
| Symptomatic coronary artery disease [69] | 8 vs 10 | 74.3 ± 11.1 vs 67.3 ± 13.6 | 28.3% NAb |
1.8% 9.1% |
7.9 ± 0.8 9.3 ± 7.9 |
12.2% |
| Sepsis trial [70] | 7 vs 9 | 67 vs 67 | 64% vs 99% | 5.9% vs 2.2% | 7.7 vs 9.3 | 82% |
Updated From Goodnough LT, Schrier A. Am J Hematol 2014;89:88–96 [4].
a
Average daily hemoglobin.
b
NA: not available.