Table 3.

Variations observed in the aa sequence of the S1 portion of the S glycoproteins of BCoV field strains associated to WD, NCD, or pneumonia, specific to virulent EBCoV strains when compared to the reference Mebus strain^a

Amino acid	Pathology and strains
EBCoV strains							RBCoV strains
NCD					WD
Mebus (HRT)	Mebus (FBK)	BCoV.Que (MDBK)	BCQ.571 (HRT)	BCQ.1523 (HRT)	BCQ.7373 (HRT)	BCQ.2590 (HRT)	OK-0514 (HRT)	BCO 43277 (HRT)	BCO 44175 (HRT)	BCQ 3994 (HRT)
154	L	*	*	*	F	F	F	*	*	*	*
182	E	*	*	K	K	K	K	*	*	*	*
196	K	*	*	*	*	N	N	*	*	*	*
215	E	*	*	K	K	K	K	*	*	*	*
273	A	*	*	P	P	P	P	*	*	*	*
320	D	*	*	N	N	N	N	*	*	*	*
509	N	*	*	*	T	T	T	*	*	*	*
759	D	*	*	V	V	*	*	*	*	*	*

^aAn asterisk (*) indicates a consensus with the reference Mebus strain.