Table 2.
Viruses used to test efficacy of viral removal/inactivation steps during IgG preparation
| Virus | Nucleic acid | Size (nm) | Human virus modeled |
|---|---|---|---|
| Enveloped viruses | |||
| HIV-1 | RNA | 80–100 | HIV 1 & 2 |
| Pseudorabies | DNA | 120–200 | Herpes |
| Bovine viral diarrhea | RNA | 50–70 | Hepatitis C |
| West Nile virus | RNA | 50–70 | West Nile |
| Nonenveloped viruses | |||
| Encephalomyocarditis | RNA | 25–30 | Hepatitis A |
| Minute virus of mice | DNA | 18–24 | Parvovirus B19 |
| Reovirus | RNA | 70 | Rotavirus |
| Porcine or bovine parvovirus | DNA | 20–30 | Parvovirus B19 |
| Prion (agent of Creutzfeldt-Jacob disease) | |||
| Rodent-adapted hamster scrapie | |||