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. 2006 Feb 7;14(3):141–147. doi: 10.1016/j.tim.2006.01.006

Table 1.

Surface display of antigenic epitopes and mimotopes on filamentous phage

Library Screened against Results Refs
12mer RPL displayed on pIII Polyclonal sera specific for Burkholderia pseudomallei protease Identification of linear and discontinuous protease epitopes of B. pseudomallei [49]
7mer RPLs displayed on pIII Purified anti-Mycoplasma hyopneumoniae IgG Identification of M. hyopneumoniae antigens. Phage clones identified by screening induced immune responses in murine model [50]
12mer RPL displayed on pIII Monoclonal IgA1 specific for the capsule of Streptococcus pneumoniae Identification of mimotopes of the capsular polysaccharide of type 8 S. pneumoniae. When conjugated to tetanus toxoid, mimotopes induced a type 8 capsular-polysaccharide-specific antibody response in mice [51]
7mer RPL displayed on pIII Sera from swine infected with Nipah virus Identification of several putative epitopes within the nucleocapsid protein of Nipah virus [52]
12mer RPL displayed on pIII Polyclonal IgG specific for neutral polysaccharides of Mycoplasma tuberculosis Isolation of phage clones that were antigenic mimotopes of B-cell epitopes of M. tuberculosis sugars. One clone invoked immune responses in rabbits [53]