Table 2.
Neutralization antibody titer in murine sera.
| Vaccine | Dose (PFU) | Routea | IC50 | IC90 |
|---|---|---|---|---|
| MVTTZCI | 106 | i.m. | 23.8 | 22.3 |
| 104 | i.m. | <2 | <2 | |
| 106 | i.n. | 24.8 | 21 | |
| 104 | i.n. | <2 | <2 | |
| VTTb | 106 | i.m. | 26.1 | 22.7 |
| 104 | i.m. | 24.5 | 21.8 | |
i.m., intramuscular inoculation; i.n., intranasal inoculation.
Since VTT kills mice via i.n., the i.n. Nab titer was not determined in this group. Neutralization antibody titer was calculated by determining the highest serum dilution (1:2 serial dilution) to achieve 50% or 90% viral inhibition.