Table 2.
Parameters studied in Tx1, PTU and old mice before and after zinc supply
| Parameters | Animal models |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Young (a) | sham-Tx (e) | Tx1 (f) | Tx2 (g) | Adult (b) | PTU (n) | Old (c) | Tx1+Zn (h) | PTU+Zn (o) | Old+Zn (d) | |
| Crude Zn balance (μg/day/mice) | +1.5±0.5 | +1.2±0.4 | −0.8±0.4* | +0.5±0.2 | +0.8±0.5 | −1.6±0.5* | −1.3±0.3* | +1.0±0.4 | +1.0±0.3 | +1.2±0.4 |
| Plasma Zn (μg/dl) | 110±11 | 98±8 | 80±6* | 90.1±3.2 | 90±7 | 82±7* | 81±6.3* | 90±4.5 | 95±6 | 91.3±3.1 |
| A.T. (log−2) | 5.2±0.3 | 5.0±0.4 | 1.0±0.4* | 1.5±0.2* | 4.2±0.4 | 1.0±0.2* | 1.0±0.2* | 2.0±0.3* | 4.0±0.3 | 4.5±0.4 |
| T.T. (log−2) | 5.2±0.2 | 5.1±0.3 | 1.0±0.4* | 1.5±0.2* | 4.5±0.3 | 4.1±0.3 | 4.0±0.3 | 2.0±0.3* | 4.2±0.3 | 4.6±0.3 |
| NK (L.U. 20/107) | 31±4 | 28±7 | 12±5* | 21±2 | 20±6 | 10±2* | 7±5* | 26±6 | 20±4 | 19±5 |
| T3 (ng/dl) | 103±6.4 | 102±7.1 | 60±4.1* | 87±4.5 | 85±3.4 | 60±10* | 45±5.3* | 92±6.1 | 90±9 | 90±3.7 |
| T4 (μg/dl) | 6.2±2.2 | 6.0±1.7 | 4.0±1.0* | 5.6±1.3 | 5.3±1.4 | 4.0±1.3 | 4.3±1.4* | 5.0±1.1 | 5.0±1.0 | 5.0±1.1 |
| TSH (μU/ml) | 2.3±0.7 | 2.1±0.8 | 3.7±1.4** | 3.3±0.7 | 3.4±1.0 | 6.0±3.1* | 3.8±1.6** | 2.5±0.8 | 2.3±1.0 | 2.4±0.6 |
| Corticost. (ng/ml) | 153±18.3 | 161±16.4 | 277±22.4* | 155±16 | 177±14.4 | 225±17.1* | 265±23.2* | 166±13.3 | 144±15 | 152±12.2 |
Ten mice/group. Mean±SD.
*
P<0.01.
**
P<0.05 when compared PTU, Old and Tx1 mice with respective controls (young-adult for old and PTU mice and sham-Tx for Tx1 mice) (two-tailed Student's t-test, ANOVA test, Bonferroni test). A restoration in nutritional–endocrine–immune profile occurs after zinc supply in Tx1, PTU and old mice when compared simultaneously with young, sham-Tx and adult mice (P>0.05) (Bonferroni test).