Scheme 1.
Synthetic pathway towards derivatives 14a–r. Reagents and conditions:(a) AcOH, CuCl, 24 h, 110 °C, 55%, (b) NaH, Toluene, EtOH, 6 h, 100 °C, 90%, (c) BnBr, K2CO3, THF, 6 h, 70 °C, 65%,(d) Toluene, 18 h, 100 °C.
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