Scheme 2.
Reagents and conditions: (a) Pd(OAc)2, XPhos, NaO-t-Bu, Toluene/t-BuOH (5:1), 18 h, 120 °C, 65%, (b) aq. HCl (5 N), 3 h, 100 °C, 45%,(c) Toluene, 18 h, 100 °C.
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