Table 1.

Molecular structures, yield and biological activity against coronavirus (229E) of derivatives 14a–r.

Entry	Compound ID	R1	R2	Yield	EC50 (μM)a
1	14a			80%	>100
2	14b			85%	>100
3	14c			65%	>100
4	14d			80%	8.95
5	14e			58%	>100
6	14f			80%	>100
7	14g			67%	>100
8	14h			48%	>100
9	14i			30%	>100
10	14j			73%	>100
11	14k			55%	>100
12	14l			56%	>100
13	14m			85%	>100
14	14n			80%	9.45
15	14o			57%	>100
16	14p			51%	>100
17	14q			50%	9.45
18	14r			60%	>100

^aConcentration required to reduce virus-induced cytopathogenicity by 50%.