Table 3.
Main pharmacokinetic parameters of luteolin, apigenin, chrysoeriol and diosmetin in rats after oral administration of 100 mg/kg FCE with or without co-administration of entacapone (20 mg/kg).
| Parameters | Apigenin |
Luteolin |
|||
|---|---|---|---|---|---|
| FCE | FCE + entacapone | FCE | FCE + entacapone | ||
| AUC (0–12) | mg/l ∗ h | 36.25 ± 16 | 54.39 ± 24 | 3.971 ± 1.2 | 5.862 ± 1.4* |
| MRT (0–12) | h | 9.46 ± 1.1 | 9.25 ± 0.9 | 2.589 ± 0.51 | 2.585 ± 0.52 |
| t1/2z | h | 18.44 ± 12 | 10.98 ± 5.2 | 2.805 ± 0.9 | 6.671 ± 7.4 |
| CLz/F | l/h/kg | 0.0876 ± 0.060 | 0.06940 ± 0.046 | 1.515 ± 0.45 | 0.818 ± 0.51 |
| Vz/F | l/kg | 2.497 ± 1.5 | 1.305 ± 0.9 | 5.975 ± 2.1 | 4.598 ± 2.8 |
| Cmax | mg/l | 3.310 ± 0.73 | 4.567 ± 1.5 | 1.684 ± 0.21 | 2.466 ± 0.69 |
| Parameters | Chrysoeriol | Diosmetin | |||
| FCE | FCE + entacapone | FCE | FCE + entacapone | ||
| AUC (0–12) | mg/l ∗ h | 1.468 ± 0.09 | 1.017 ± 0.17*** | 2.869 ± 0.74 | 2.329 ± 0.67 |
| MRT (0–12) | h | 10.66 ± 1.1 | 11.07 ± 0.8 | 6.568 ± 0.8 | 6.869 ± 0.39 |
| t1/2z | h | 26.24 ± 9 | 29.80 ± 36 | 7.359 ± 1.5 | 7.566 ± 1.6 |
| CLz/F | L/h/kg | 1.790 ± 0.60 | 1.587 ± 0.9 | 1.773 ± 0.54 | 2.133 ± 0.50 |
| Vz/F | L/kg | 61.84 ± 12 | 59.26 ± 50 | 18.37 ± 5.2 | 23.58 ± 9 |
| Cmax | mg/l | 0.0931 ± 0.028 | 0.06404 ± 0.025 | 0.3294 ± 0.052 | 0.3108 ± 0.074 |
Data are expressed as mean ± SD, n = 5; *: P < 0.05,**: P < 0.01 compared with the FCE group.