Table 1.
Antioxidant activity of DMY.
| Study model | Method/Assay | Results | References |
|---|---|---|---|
| Linoleic acid system | DPPH and reducing power | Anti-oxidative activity of flavonoid-rich extracts (DMY) comparable with that of tertiary butylhydroquinone (TBHQ) | Gao et al. (2009) |
| linoleic acid | lipid peroxidation | DMY greatly inhibit the increase of lipid peroxidation (LPO) values in a concentration dependent manner | Zhang et al. (2003) |
| Lard oil | DPPH | Effective in quenching DPPH with IC50 of 21.48 μM. Superior to that of TBHQ | Zhao et al. (2009) |
| Soybean oil | Peroxide value, anisidine value, headspace volatiles | DMY was more potent than butylated hydroxyanisole (BHA) in preventing soybean oil oxidation | Ye et al. (2015) |
| Guizhou sausage | Peroxide value (POV) malondialdehyde (MDA) | Inhibit the oxidation of sausage and its antioxidant effect increased with the increase of the amount of DMY. | Wang et al. (2017) |
| Cooked ground beef | Thiobarbituric acid reactive substances | DMY showed a high antioxidant activity and comparable with that of BHA after treatment with longer time (Day 14). | Ye et al. (2015) |
| L02 and HepG2 cells | Oleic acid-induced lipid accumulation | DMY decreased cellular triglycerides (TG), cholesterol (TC) and MDA, increased the level of superoxide dismutase (SOD) | Xie et al. (2016) |
| HUVECs | SOD,MDA, ROS, nitric oxide (NO) | DMY inhibited intracellular ROS overproduction and attenuated H2O2-induced decrease in cell viability and apoptosis, | Hou et al. (2015) |
| MG63 cells | H2O2-induced oxidative stress | 30 μM dose of DMY prevents hydrogen peroxide induced reduction in viability and apoptotic alterations | Wang et al., 2016b, Wang et al., 2016a, Wang et al., 2016c, Wang et al., 2016d, Wang et al., 2016e |
| Cisplatin-treated mouse model | SOD, MDA, catalase activity (CAT) | DMY decreased MDA level and increased CAT and SOD activities in mouse kidney tissues after treatment with cisplatin | Wu et al. (2016) |
| Neonatal rat cardiomyocytes | ROS,MDA,SOD, T-AOC | Reduced levels of MDA, increased SOD activity, T-AOC (total antioxidant capacity) and NO bioactivity by DMY | Meng et al. (2015) |
| Ang-II induced cardiac fibroblasts | ROS,MDA,SOD, T-AOC |
DMY significantly decreased ROS production and MDA level, while increased the SOD activity and T-AOC. | Song et al. (2017) |
| LDL receptor deficient mice | ROS,MDA,SOD, CAT, glutathione (GSH) | DMY decreased ROS production and MDA level, increased SOD, GSH and CAT levels. | Liu, Zeng, et al. (2017) |