Table 3.
List of various resources for drug repurposing.
| Sl.no | Resources | Repurposing Approaches | Website link |
|---|---|---|---|
| 1 | Pubmed | Text Mining approach | https://www.ncbi.nlm.nih.gov/pubmed/ |
| 2 | Online Mendelian Inheritance in Animals (OMIA) | Text Mining approach | https://omia.org/home/ |
| 3 | Drugbank | Pharmacological databases | http://www.drugbank.ca/ |
| 4 | Drug versus Disease (DvD) | Pharmacological databases | www.ebi.ac.uk/saezrodriguez/dvd |
| 5 | Drug Combination Database (DCDB) | Pharmacological databases | http://www.cls.zju.edu.cn/dcdb |
| 6 | Drug Map Central (DMC) | Pharmacological databases | http://r2d2drug.org/index.html |
| 7 | Side Effect Resource (SIDER) | Pharmacological databases | http://sideeffects.embl.de |
| 8 | DailyMed (US FDA) | Medical database | http://dailymed.nlm.nih.gov/dailymed/about.cfm |
| 9 | Drugs@FDA Database | Medical database | http://www.fda.gov/Drugs/InformationOnDrugs/ |
| 10 | FAERS (US FDA) | Medical database | http://www.fda.gov/Drugs/ |
| 11 | FDALABEL (US FDA) | Medical database | https://labels.fda.gov/ |
| 12 | ChemBank | Chemical databases | http://chembank.broad.harvard.edu |
| 13 | ChEMBL | Chemical databases | https://www.ebi.ac.uk/chembl/ |
| 14 | ChemDB | Chemical databases |
http://www.chemdb.com (Service is currently not available) |
| 15 | ChemDB | Chemical databases | http://www.chemdb.com |
| 16 | PubChem | Chemical databases | https://pubchem.ncbi.nlm.nih.gov/ |
| 17 | BindingDB | Chemical databases | http://www.bindingdb.org/bind/index.jsp |
| 18 | ChemFrog | Chemical databases |
http://www.chemfrog.com (Service is currently not available) |
| 19 | Chemicalize (ChemAxon) | Chemical databases | http://www.chemicalize.org |
| 20 | ChemSpider | Chemical databases | http://www.chemspider.com |
| 21 | Protein Data Bank (PDB) | Proteomics databases | http://www.rcsb.org/pdb/home/home.do |
| 22 | Database of Interacting Proteins (DIP) | Proteomics databases | http://dip.doe-mbi.ucla.edu/dip/Main.cgi |
| 23 | Human Protein Reference Database (HPRD) | Proteomics databases | http://www.hprd.org/ |
| 24 | IntAct Molecular Interaction Database | Proteomics databases | http://www.ebi.ac.uk/intact/ |
| 25 | OCA | Proteomics databases | http://oca.weizmann.ac.il/oca-bin/ocamain |
| 26 | Sequence Read Archive (SRA) | Proteomics databases | http://www.ncbi.nlm.nih.gov/Traces/sra/ |
| 27 | Oncomine | Genomics database | https://www.oncomine.org |
| 28 | Online Mendelian Inheritance in Man (OMIM) | Genomics database | http://www.omim.org |
| 29 | Pharmacogenomics Knowledge Base (PharmGKB) | Genomics database | http://www.pharmgkb.org |
| 30 | ArrayExpress | Genomics database | http://www.ebi.ac.uk/arrayexpress/ |
| 31 | Kyoto Encyclopedia of Genes and Genomes (KEGG) | Genomics database | http://www.genome.jp/kegg |
| 32 | CellMiner | Genomics database | http://discover.nci.nih.gov/cellminer/ |
| 33 | Database for Annotation Visualization and Integrated Discovery (DAVID) | Genomics database | http://david.abcc.ncifcrf.gov |
| 34 | DbSNP | Genomics database | http://www.ncbi.nlm.nih.gov/projects/SNP/ |
| 35 | Gene Expression Atlas | Genomics database | http://www.ebi.ac.uk/gxa |
| 36 | Gene Expression Omnibus (GEO) | Genomics database | http://www.ncbi.nlm.nih.gov/geo |
| 37 | Gene Set Enrichment Analysis(GSEA) | Genomics database | http://www.broadinstitute.org/gsea |
| 38 | GeneCards Databases | Genomics database | http://www.genecards.org/ |
| 39 | International Cancer Genome Consortium | Genomics database | https://icgc.org |
| 40 | Molecular Signature Database(MsigDB) | Genomics database | http://www.broadinstitute.org/gsea/msigdb |
| 41 | Mammalian protein-protein interaction database (MIPS) | Heterogenous networks | http://mips.helmholtz-muenchen.de/proj/ppi/ |
| 42 | Search tool for interactions of chemicals (STRING) | Biological database/Proteomics databases | http://string-db.org/ |
| 43 | Biological General Repository for Interaction Datasets (BioGRID) | Biological database | http://thebiogrid.org/ |
| 44 | Cancer Cell Line Encyclopedia (CCLE) | Biological database | http://www.broadinstitute.org/ccle |
| 45 | GPCR-Ligand Database (GLIDA) | Biological approach | http://pharminfo.pharm.kyoto-u.ac.jp/services/glida/ |
| 46 | NCI Pathway Interaction Database (NCI-PID) | Biological approaches |
http://pid.nci.nih.gov/ (Service is currently not available) |
| 47 | OPM(membrane proteins) | Biological approaches | http://opm.phar.umich.edu |
| 48 | Pathway Commons | Biological approaches | http://www.pathwaycommons.org/about/ |
| 49 | Psychoactive Drug Screening Program Ki (PDSP Ki) | Biological approaches | https://pdspdb.unc.edu/pdspWeb/ |
| 50 | Reactome | Biological approaches | http://www.reactome.org |
| 51 | Human Metabolome Database (HMDB) | Metabolomics databases | http://www.hmdb.ca |
| 52 | Clinicaltrial.gov | Experimental approaches | http://clinicaltrials.gov |
| 53 | Library of Integrated Network based Cellular Signatures(LINCS) | Experimental approaches | http://www.lincsproject.org |
| 54 | NCGC Database | Experimental approaches | https://tripod.nih.gov/npc/ |
| 55 | Princeton University MicroArray database (PUMAdb) | Experimental approaches | http://puma.princeton.edu |
| 56 | Stanford Microarray Database | Experimental approaches |
http://smd.princeton.edu (Service is currently not available) |
| 57 | Collaborative Drug Discovery Vault | Mixed approaches | https://www.collaborativedrug.com |
| 58 | STITCH (Chemical-Protein Interactions) | Mixed approaches | http://stitch.embl.de/ |
| 59 | SWEETLEAD | Mixed approaches | https://simtk.org/home/sweetlead |
| 60 | The Cancer Genome Atlas (TCGA) | Mixed approaches | http://cancergenome.nih.gov |
| 61 | The Connectivity Map (CMap) | Mixed approaches | http://www.broadinstitute.org/cmap |
| 62 | The NCGC Pharmaceutical Collection (NPC) | Mixed approaches | http://tripod.nih.gov/npc/ |
| 63 | TOPSAN | Mixed approaches |
http://www.topsan.org (Service is currently not available) |
| 64 | DistilBio | Knowledge based approach | http://distilbio.com |
| 65 | Proteopedia | Knowledge-based repurposing | http://proteopedia.org |
| 66 | Pharmacogenomics Knowledge Base (PharmGKB) | Knowledge based approach | http://www.pharmgkb.org |
| 67 | Therapeutic Target Database (TTD) | Knowledge based approach | http://bidd.nus.edu.sg/group/cjttd/ |