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Physicochemical properties of the different siRNA preparations. Results are means ± SD of three samples.
| Particle size (nm) | Polydispersity | Zeta potential (mV) | siRNA loading efficiency (%) | |
|---|---|---|---|---|
| Plain-PLGA NS | 317.6 ± 5.8 | 0.102 ± 0.01 | −31.1 ± 2.3 | 28.3 ± 4.5 |
| CS-modified PLGA NS | 352.8 ± 10.3 | 0.229 ± 0.03 | 11.2 ± 1.9 | 44.5 ± 6.6 |
| siRNA/NS complex | 325.3 ± 14.7 | 0.216 ± 0.02 | 6.6 ± 3.1 | – |
| siRNA/DOTAP complex | 225.4 ± 3.9 | 0.097 ± 0.02 | 44.7 ± 3.0 | – |
