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Safety testing of IBV YX10 at different passages.
| Group | Passage level/vaccine/control | Dosagea (EID50) | Morbidity | Mortality |
|---|---|---|---|---|
| 1 | p5 | 104.5 | 12/12 | 3/12 |
| 2 | p25 | 104.5 | 12/12 | 2/12 |
| 3 | p58 | 104.5 | 9/12 | 1/12 |
| 4 | p75 | 104.5 | 0/12 | 0/12 |
| 5 | p90 | 104.5 | 0/12 | 0/12 |
| 6 | p102 | 104.5 | 0/12 | 0/12 |
| Vaccine | H120 | 104.5 | 0/12 | 0/12 |
| Control | PBS | 0/12 | 0/12 |
Seven-day-old SPF chickens were inoculated with 10 doses of IBV (passaged virus 105.5 EID50/bird or vaccine strain H120 104.5 EID50/bird) via the intranasal route.
