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Anti-HIV-1 and HIV-2 activities of compounds 1–14 in human T-lymphocyte (CEM) cells
| Compound | EC50 (μM) |
|
|---|---|---|
| HIV-1 | HIV-2 | |
| 1 | ⩾50 | ⩾50 |
| 2 | >50 | >50 |
| 3 | 35 | ⩾50 |
| 4 | 10 | >50 |
| 5 | >250 | >250 |
| 6 | >10 | >10 |
| 7 | >2 | >2 |
| 8 | ⩾50 | ⩾50 |
| 9 | >50 | >50 |
| 10 | ⩾10 | ⩾10 |
| 11 | >50 | >50 |
| 12 | ⩾10 | ⩾10 |
| 13 | >10 | >10 |
| 14 | 14 | 3.1 |
EC50, effective concentration or concentration required to protect CEM cells against the cytopathogenicity of HIV by 50%.
