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Anti-HBV activity and cytotoxicity of Compound 1 in vitro at day 9 of treatment
| Compound (μmol/L) | Cytotoxicity | HBV DNA |
HBeAg |
HBsAg |
|||
|---|---|---|---|---|---|---|---|
| CC50a | IC50b | SI | IC50b | SI | IC50b | SI | |
| Compound 1 | 1747 | 3.72 | 469.0 | 75 | 23.0 | 80.00 | 21.0 |
| ADV | 1995 | 30.09 | 66.3 | 296 | 6.7 | 266.00 | 7.5 |
Selectivity index was determined as the CC50/IC50 value.
The cytotoxicity concentration of Compound 1 or ADV that reduced cell viability to 50% (CC50).
The concentrations of Compound 1 or ADV needed to inhibit.
