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Numbers of hydrophobic contacts between residues of SARS-CoV Mpro and group II compounds in the Cys–S1 binding mode
| Residues | Number of hydrophobic contacts |
||||||
|---|---|---|---|---|---|---|---|
| 6 | 7 | 8 | 9 | 10 | 11 | 12 | |
| His41 | 2 | 2 | 2 | 2 | 6 | ||
| Met49 | 3 | ||||||
| Phe140 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| Leu141 | 3 | 2 | 2 | 2 | 2 | 3 | 3 |
| Asn142 | 1 | ||||||
| Cys145 | 3 | 3 | 3 | 3 | 3 | ||
| His163 | 1 | 1 | 1 | 2 | 1 | 1 | |
| His164 | 2 | 2 | 1 | 1 | |||
| Met165 | 3 | 3 | 3 | 4 | 7 | 8 | |
| Glu166 | 6 | 6 | 6 | 7 | 6 | 6 | 3 |
| His172 | 1 | 1 | 1 | 1 | |||
| Total | 23 | 22 | 21 | 17 | 18 | 26 | 22 |
