Fig. 1.

A typical virus life cycle. Despite the diversity of genomic organization and mechanisms of replication found among virus families, most viruses pass through several common stages during the infection process. Host resistance factors that determine the outcome of virus infection exist at each of the following stages: 1, viral attachment and entry into the host cell; 2, virus multiplication inside the host cell; 3, recognition and lysis of virus-infected cells. Mouse genes affecting susceptibility are shown in yellow boxes, human genes are shown in green boxes.