Table 1.

Mouse loci affecting susceptibility to viral infections^a

Virus	Locus	Locus definition	Chromosome locationb	Gene product	Mode of actionc
Coronaviridae
Mouse hepatitis virus-2	Hv1				Provides viral entry receptor
Mouse hepatitis virus-4	Hv2	Controls resistance of peritoneal macrophage to infection	7 (5.5 cM)	CEACAM1	Provides viral entry receptor
Retroviridae
Ecotropic murine leukemia virus (MuLV)	Fv1	Influences susceptibility to FV-induced erythroleukemia	4 (76.5 cM)	Endogenous gag-related gene	Blocks viral preintegration complex
Spleen focus-forming virus (SFFV)	Fv2	Controls resistance to spleen focus formation	9 (60 cM)	STK	Truncated STK results in expansion of infected cell in the primary phase of erythroleukemia
Ecotropic MuLV	Fv4/Akvr1	Controls resistance to Friend MuLV	12 (38 cM)	Ecotropic Env protein	Blocks ecotropic virus receptor
Mink cell focus-forming (MCF) virus	Rmcf	Confers resistance to the polytropic MCF virus	5 (10 cM)	Polytropic Env protein	Blocks polytropic virus receptor
Friend virus (FV)	Rfv1	Influences susceptibility to FV-induced disease	17	H2-D	Induces an efficient cytotoxic T lymphocyte (CTL) response
	Rfv2	Modulates FV-induced disease	17	H2-linked
	Rfv3	Influences susceptibility to FV-induced disease	15		Produces vigorous antivirus antibody response
Moloney murine leukemia virus (MoMLV)	Rmv1	Increases IgG-specific anti-MoMLV response	17	H2-linked	Controls antibody responses against infection
	Rmv2	Increases IgG-specific anti-MoMLV response	17	H2-linked	Controls antibody responses against infection
	Rmv3	Increases IgG-specific anti-MoMLV response	17	H2-linked	Controls antibody responses against infection
Orthomyxoviridae
Influenza virus and Thogoto virus	Mx1	Rescues lethal infection	16 (71.2 cM)	GTPase	Blocks primary transcription and facilitates the degradation of the viral ribonucleoprotein complexes
Rhabdoviridae
Vesicular stomatitis virus	Mx2	Rescues lethal infection	16 (71.2 cM)	GTPase	Blocks trafficking of the viral ribonucleoprotein complexes
Flaviviridae
Flavivirus	Flv	Controls virus replication of flavivirus infection in mouse brain	5 (67 cM)	OAS1B	Induces RNA degradation by activating RNase L
Herpesviridae
Murine cytomegalovirus	Cmv1	Controls viral replication on spleen	6 (63.29 cM)	Ly49H	Recognizes and kills viral-infected cells
	H2	Serves as receptor for mouse cytomegalovirus (MCMV)	17	H2	Provides viral entry receptor
Herpes simplex virus	Rhs1	Controls early primary infection	6
γ-Herpesvirus	Trbv4c1	Results in increased Vbeta4+ T cells	17 (23 cM)
	Trbv4c2	Results in increased Vbeta4+ T cells	6 (0.5 cM)
Picornaviridae
Theiler's virus	Tmevd1	Confers resistance to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease	6 (22 cM)
	Tmevd2	Confers resistance to TMEV-induced demyelinating disease	3 (43 cM)
	Tmevd3	Confers resistance to TMEV-induced demyelinating disease	14
	Tmevd4	Confers resistance to TMEV-induced demyelinating disease	14
	Tmevd5	Confers resistance to TMEV-induced demyelinating disease	11 (52 cM)
	Tmevp1	Controls susceptibility to persistent infection	17	H2-Db	Induces an efficient CTL response
	Tmevp2	Controls susceptibility to persistent infection	10 (67 cM)
	Tmevp3	Controls susceptibility to persistent infection	10 (60 cM)
Poxviridae
Mousepox virus	Rmp1	Rescues lethal infection	6		NK cell mediated
	Rmp2	Rescues lethal infection	2 (23.5 cM)
	Rmp3	Rescues lethal infection	17 (19.5 cM)	H2-Db
	Rmp4	Controls virus replication in spleen and liver	1 (79 cM)
Togaviridae
Sindbis virus	Nsv1	Reduces levels of viral RNA in the brain	2

^aBased on information available in Mouse Genome Informatics at Jackson Laboratory (http://www.informatics.jax.org).

^bChromosome number, with map distance to centromere in centimorgans (cM) in parentheses.

^cThe mechanisms of action of some genes are hypothetical.