Table 2.

Host genes primarily associated with susceptibility to viral infections in humans^a

Virus	Affected gene	OMIMb	Chromosome location	Polymorphisms	Consequences	Refs
Retroviridae
HIV	CCR5	601373	3p21	Deletion	Resistance to HIV infection	[10]
	CCR2	601267	3p21	Point mutation	Delayed progression to AIDS	[10]
	CXCL12 3′UTR	600835	10q11.1	Point mutation	Delayed progression to AIDS	[10]
	MBL2	154545	10q11.2–q21	Point mutation	Increased susceptibility to HIV infection	[70]
	IL10 promoter	124092	1q31–q32	Point mutation	Accelerated progression to AIDS	[71]
Hepadnaviridae
Hepatitis B	TNF-α promoter	191160	6p21.3	Point mutation	Increased hepatitis B virus (HBV) persistence	[41]
	MBL2	154545	10q11.2–q21	Point mutation	Increased HBV persistence	[72]
	VDR	601769	12q12–q14	Point mutation	Decreased HBV persistence	[73]
Herpesviridae
Epstein–Barr virus (EBV)	SH2D1A	308240	Xq25	Various	Development of X-linked lymphoproliferative disease (XLP) following infection by EBV	74, 75

^aMutations in several genes associated with immunodeficiency, such as severe combined immunodeficiency (SCID), also result in increased susceptibility to various pathogens, including viruses, and are not listed here.

^bOnline Mendelian Inheritance in Man (http://www.ncbi.nlm.nih.gov/Omim).