Table 3.

Lavage levels of LTB4 after LTB4 challenge.

LTB4 (μg)	LTB4 (ng/ml)
	Prior	1 h	4 h
0 (Sham)	0.46 (0.18)	0.48 (0.19)	0.42 (0.21)
2.0	0.50 (0.25)	1.16 (2.23)∗∗∗	0.42 (0.28)
20	0.47 (0.59)	17.45 (23.15)∗∗∗	0.69 (1.28)∗∗∗

Median levels (interquartile ranges) of LTB4 in nasal lavages obtained prior to nasal challenge with sham and two doses of LTB4 as well as 1 and 4 h thereafter. Levels of LTB4 significantly increased 1 h following challenges with 2 and 20 μg LTB4. Approximately 1% of the administered dose of LTB4 was retrievable by lavage at 4 h post challenge, approaching baseline values. Comparisons are made with sham challenge at each time-point (^∗∗∗ denotes p < 0.001.)