Table 4.
Lavage levels of IL-8, ECP, and α2-macroglobulin after LTB4 challenge.
| LTB4 (μg) | IL-8 (pg/ml) |
ECP (ng/ml) |
α2-macroglobulin (μg/ml) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Prior | 1 h | 4 h | Prior | 1 h | 4 h | Prior | 1 h | 4 h | |
| Sham | 171 (244) | 79 (130) | 50 (88) | 0 (4.5) | 0 (3.9) | 0 (2.2) | 0.2 (0.2) | 0 (0.1) | 0 (0.1) |
| 2.0 | 136 (188) | 94 (103) | 67 (82) | 0 (6.2) | 2.0 (5.0) | 0 (3.0) | 0 (0.2) | 0 (0.2) | 0 (0.1) |
| 20 | 148 (202) | 81 (106) | 65 (86) | 0 (3.5) | 0 (6.2) | 0 (3.8) | 0 (0.3) | 0 (0.2) | 0 (0.1) |
Median levels (interquartile ranges) of analytes in nasal lavages obtained prior to nasal challenge with sham and two doses of LTB4 as well as 1 and 4 h thereafter. LTB4 failed to affect the levels of IL-8, ECP, and α2-macroglobulin. Comparisons are made with sham challenge at each time-point (all statistically non-significant).