Table 5.
Cytotoxicity against MT-4, MDBK, BHK and Vero-76 cell lines and YFV, Reo-1, CVB-2, RSV, HSV-1 and Sb-1 inhibitory activity of triazene derivatives of structure F and G
| Compda | X | R | MT-4 CC50b | MDBK CC50c | BHK-21 CC50e | YFV EC50f | Reo-1 EC50g | VERO-76 CC50h | CVB-2 EC50i | RSV EC50j | HSV-1 EC50k | Sb-1 EC50l |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 34 | Nil | H | >100 | >100 | ⩾100 | >100 | >100 | >100 | >100 | ⩾100 | >100 | >100 |
| 35 | Nil | 3-Cl | >100 | >100 | >100 | >100 | >100 | ⩾100 | >100 | >100 | >100 | ⩾100 |
| 36 | Nil | 3-Br | >100 | >100 | >100 | >100 | >100 | ⩾100 | >100 | >100 | >100 | >100 |
| 37 | Nil | 3-CF3 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 38 | Nil | 3-NO2 | 66 | >100 | 42 | >42 | >42 | 80 | >80 | 8 | >80 | 30 |
| 39 | Nil | 4-Cl | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 42 |
| 40 | Nil | 4-Br | >100 | >100 | >100 | >100 | >100 | ⩾100 | >100 | >100 | >100 | 51 |
| 41 | Nil | 4-NO2 | ⩾100 | >100 | ⩾100 | >100 | >100 | 90 | >90 | 60 | >90 | 15 |
| 42 | Nil | 4-OCH3 | 68 | 60 | ⩾100 | >100 | >100 | 90 | >90 | >90 | >90 | >90 |
| 43 | Nil | 2,5-diF | >100 | >100 | >100 | >100 | >100 | >100 | 35 | >100 | >100 | 44 |
| 44 | Nil | 3,4-diCl | 75 | 70 | 50 | >50 | >50 | 58 | >58 | 20 | >58 | 25 |
| 45 | CH2 | H | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 46 | CH2 | 3-Cl | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 47 | CH2 | 3-Br | >100 | >100 | >100 | >100 | >100 | 85 | >85 | >85 | >85 | >85 |
| 48 | CH2 | 3-NO2 | >100 | >100 | >100 | >100 | >100 | 83 | >83 | >83 | >83 | >83 |
| 49 | CH2 | 4-Cl | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 50 | CH2 | 4-Br | >100 | >100 | >100 | >100 | >100 | >100 | 25 | 73 | >100 | >100 |
| 51 | CO | H | >100 | ⩾100 | 90 | >90 | >90 | 60 | 13 | >60 | >60 | >60 |
| 52 | N-CH3 | H | 65 | >100 | 70 | >70 | >70 | 45 | 14 | >45 | >45 | >45 |
| 53 | N-CH3 | 2,5-diF | >100 | >100 | >100 | 50 | 30 | ⩾100 | 71 | >100 | 64 | >100 |
| 54 | N-COOC2H5 | H | 100 | >100 | >100 | >100 | >100 | 90 | 30 | >90 | >90 | >90 |
| 55 | N-Ph | H | 33 | >100 | >100 | >100 | >100 | ⩾100 | >100 | 8 | >100 | >100 |
| 56 | N-2-Pyrimidinyl | H | 90 | >100 | >100 | >100 | >100 | 65 | 10 | >65 | >65 | >65 |
| 57 | 4-Cl | 46 | 97 | 85 | >85 | >85 | 55 | >55 | >55 | >55 | >55 | |
| 58 | 3-NO2 | >100 | >100 | >100 | >100 | 80 | 90 | >90 | ⩾90 | >90 | >90 | |
| NM-108 | >100 | >100 | 90 | 1.8 | 2.4 | >100 | 20 | >100 | >100 | >100 | ||
| NM 299 | 2 | >100 | >100 | 26 | >100 | 20 | >20 | 1.2 | >20 | >20 | ||
| ACG | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 3 | >100 | ||
| Ribavirin | 31 | >100 | >100 | >100 | >100 | >100 | >100 | 7 | >100 | >100 | ||
| NM 176 | ⩾100 | >100 | >100 | >100 | >100 | >100 | 24 | >100 | >100 | 20 | ||
| M 5255 | 0.2 | 42 | >100 | >100 | >100 | ⩾13 | >13 | 0.6 | >13 | >13 | ||