Table 2.
Antiviral activities1 of bovine colostrums (BC)
| BC and virus2 (strain) | EC50 (μg/mL) (95% CI) | EC90 (μg/mL) (95% CI) | CC50 (μg/mL) | SI |
|---|---|---|---|---|
| Nonimmune BC | ||||
| HSV-1 | NA3 | NA | >6,680 | — |
| HSV-2 | NA | NA | >6,680 | — |
| HCMV | NA | NA | >6,680 | — |
| HRhV | NA | NA | >6,680 | — |
| HRoV (Wa) | 2.3 (1.6–3.5) | 16.3 (6.8–39.1) | >6,680 | >2,855 |
| HRoV (HRV408) | 12.6 (8.6–18.7) | 90 (38–215) | >6,680 | >529 |
| HRoV (HRV248) | 4.2 (2.4–7.3) | 134 (39–454) | >6,680 | >1,591 |
| BRoV (NCDV) | 61 (44–86) | 143 (97–211) | >6,680 | >109 |
| VSV | 64 (55–75) | 343 (252–467) | >6,680 | >104 |
| Hyperimmune BC | ||||
| HSV-1 | NA | NA | >7,140 | — |
| HSV-2 | 6,018 (2,560–14,110) | NA | >7,140 | >1.18 |
| HCMV | NA | NA | >7,140 | — |
| HRhV | NA | NA | >7,140 | — |
| HRoV (Wa) | 0.3 (0.3–0.5) | 4.5 (2.4–8.5) | >7,140 | >21,000 |
| HRoV (HRV408) | 2.1 (1.7–2.6) | 7.6 (4.7–12.5) | >7,140 | >3,449 |
| HRoV (HRV248) | 1.6 (1.2–2.8) | 8.1 (5.6–11.6) | >7,140 | >4,519 |
| BRoV (NCDV) | 5.5 (3.7–8.2) | 51 (21–122) | >7,140 | >1,301 |
| VSV | 89 (60–132) | 489 (200–1198) | >7,140 | >80 |
1
EC50 = half-maximal effective concentration; EC90 = 90% effective concentration; CC50 = half-maximal cytotoxic concentration; SI = selectivity index (CC50/EC50).
22
HSV-1 = herpes simplex type 1; HSV-2 = herpes simplex type 2; HCMV = human cytomegalovirus; HRhV = human rhinovirus; HRoV = human rotavirus; BRoV = bovine rotavirus; VSV = vesicular stomatitis virus.
3
Not assessable.